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stat3-specific inhibitor s3i-201  (ApexBio)

 
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    ApexBio stat3-specific inhibitor s3i-201
    Stat3 Specific Inhibitor S3i 201, supplied by ApexBio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/stat3+specific+inhibitor+s3i-201/pmc05874413-424-24-27?v=ApexBio
    Average 90 stars, based on 1 article reviews
    stat3-specific inhibitor s3i-201 - by Bioz Stars, 2026-08
    90/100 stars

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    ( A and B ) Representative Western blot ( A ) and quantification ( B ) of SMAD3, p-SMAD3, ERK, p-ERK, P38, p-P38, JNK, p-JNK, AKT, p-AKT, <t>STAT3,</t> and p-STAT3 in atrial tissue of indicated group. n = 6–7/group. Statistical analyses: 1-way ANOVA with Bonferroni’s post hoc test ( B ); * P < 0.05, *** P < 0.001 versus sham; ## P < 0.01, ### P < 0.001 versus vehicle. Data are expressed as the mean ± SEM.
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    ( A and B ) Representative Western blot ( A ) and quantification ( B ) of SMAD3, p-SMAD3, ERK, p-ERK, P38, p-P38, JNK, p-JNK, AKT, p-AKT, <t>STAT3,</t> and p-STAT3 in atrial tissue of indicated group. n = 6–7/group. Statistical analyses: 1-way ANOVA with Bonferroni’s post hoc test ( B ); * P < 0.05, *** P < 0.001 versus sham; ## P < 0.01, ### P < 0.001 versus vehicle. Data are expressed as the mean ± SEM.
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    ( A and B ) Representative Western blot ( A ) and quantification ( B ) of SMAD3, p-SMAD3, ERK, p-ERK, P38, p-P38, JNK, p-JNK, AKT, p-AKT, <t>STAT3,</t> and p-STAT3 in atrial tissue of indicated group. n = 6–7/group. Statistical analyses: 1-way ANOVA with Bonferroni’s post hoc test ( B ); * P < 0.05, *** P < 0.001 versus sham; ## P < 0.01, ### P < 0.001 versus vehicle. Data are expressed as the mean ± SEM.
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    stat3-specific inhibitor s3i-201  (ApexBio)
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    ( A and B ) Representative Western blot ( A ) and quantification ( B ) of SMAD3, p-SMAD3, ERK, p-ERK, P38, p-P38, JNK, p-JNK, AKT, p-AKT, <t>STAT3,</t> and p-STAT3 in atrial tissue of indicated group. n = 6–7/group. Statistical analyses: 1-way ANOVA with Bonferroni’s post hoc test ( B ); * P < 0.05, *** P < 0.001 versus sham; ## P < 0.01, ### P < 0.001 versus vehicle. Data are expressed as the mean ± SEM.
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    stat3 specific inhibitor s3i-201  (ApexBio)
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    ( A and B ) Representative Western blot ( A ) and quantification ( B ) of SMAD3, p-SMAD3, ERK, p-ERK, P38, p-P38, JNK, p-JNK, AKT, p-AKT, <t>STAT3,</t> and p-STAT3 in atrial tissue of indicated group. n = 6–7/group. Statistical analyses: 1-way ANOVA with Bonferroni’s post hoc test ( B ); * P < 0.05, *** P < 0.001 versus sham; ## P < 0.01, ### P < 0.001 versus vehicle. Data are expressed as the mean ± SEM.
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    s3i-201 (a stat3-specific inhibitor)  (Millipore)
    90
    Millipore s3i-201 (a stat3-specific inhibitor)
    ( A and B ) Representative Western blot ( A ) and quantification ( B ) of SMAD3, p-SMAD3, ERK, p-ERK, P38, p-P38, JNK, p-JNK, AKT, p-AKT, <t>STAT3,</t> and p-STAT3 in atrial tissue of indicated group. n = 6–7/group. Statistical analyses: 1-way ANOVA with Bonferroni’s post hoc test ( B ); * P < 0.05, *** P < 0.001 versus sham; ## P < 0.01, ### P < 0.001 versus vehicle. Data are expressed as the mean ± SEM.
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    Image Search Results


    ( A and B ) Representative Western blot ( A ) and quantification ( B ) of SMAD3, p-SMAD3, ERK, p-ERK, P38, p-P38, JNK, p-JNK, AKT, p-AKT, STAT3, and p-STAT3 in atrial tissue of indicated group. n = 6–7/group. Statistical analyses: 1-way ANOVA with Bonferroni’s post hoc test ( B ); * P < 0.05, *** P < 0.001 versus sham; ## P < 0.01, ### P < 0.001 versus vehicle. Data are expressed as the mean ± SEM.

    Journal: JCI Insight

    Article Title: TRPV4 blockade suppresses atrial fibrillation in sterile pericarditis rats

    doi: 10.1172/jci.insight.137528

    Figure Lengend Snippet: ( A and B ) Representative Western blot ( A ) and quantification ( B ) of SMAD3, p-SMAD3, ERK, p-ERK, P38, p-P38, JNK, p-JNK, AKT, p-AKT, STAT3, and p-STAT3 in atrial tissue of indicated group. n = 6–7/group. Statistical analyses: 1-way ANOVA with Bonferroni’s post hoc test ( B ); * P < 0.05, *** P < 0.001 versus sham; ## P < 0.01, ### P < 0.001 versus vehicle. Data are expressed as the mean ± SEM.

    Article Snippet: In another group of experiments, cells were preincubated with AKT specific inhibitor LY294002 (40 μM, Selleckchem), STAT3 specific inhibitor S3I-201 (50 μM, Selleckchem), P38 inhibitor SB 203580 (10 μM, Selleckchem), or SMAD3 inhibitor SIS3 (3 μM, Selleckchem) for 30 minutes before GSK1016790A treatment.

    Techniques: Western Blot

    ( A ) The mRNA expression of α-SMA, collagen-1, and collagen-3 by real-time polymerase chain reaction (PCR). n = 4/group. ( B ) Proliferation of CFs by BrdU assay. Cells were treated with DMSO or GSK1016790A, or with GSK2193874 or GSK2193874 + multiple signaling pathway inhibitors. LY294002, an AKT inhibitor; S3I-201, a STAT3 specific inhibitor; SB 203580, P38 inhibitor; or SIS3, a SMAD3 inhibitor. n = 4/group, each in triplicate. Statistical analyses: 1-way ANOVA with Bonferroni’s post hoc test ( D ); * P < 0.05, ** P < 0.01, *** P < 0.001 versus DMSO; # P < 0.05, ## P < 0.01, ### P < 0.001 versus GSK1016790A. Data are expressed as the mean ± SEM.

    Journal: JCI Insight

    Article Title: TRPV4 blockade suppresses atrial fibrillation in sterile pericarditis rats

    doi: 10.1172/jci.insight.137528

    Figure Lengend Snippet: ( A ) The mRNA expression of α-SMA, collagen-1, and collagen-3 by real-time polymerase chain reaction (PCR). n = 4/group. ( B ) Proliferation of CFs by BrdU assay. Cells were treated with DMSO or GSK1016790A, or with GSK2193874 or GSK2193874 + multiple signaling pathway inhibitors. LY294002, an AKT inhibitor; S3I-201, a STAT3 specific inhibitor; SB 203580, P38 inhibitor; or SIS3, a SMAD3 inhibitor. n = 4/group, each in triplicate. Statistical analyses: 1-way ANOVA with Bonferroni’s post hoc test ( D ); * P < 0.05, ** P < 0.01, *** P < 0.001 versus DMSO; # P < 0.05, ## P < 0.01, ### P < 0.001 versus GSK1016790A. Data are expressed as the mean ± SEM.

    Article Snippet: In another group of experiments, cells were preincubated with AKT specific inhibitor LY294002 (40 μM, Selleckchem), STAT3 specific inhibitor S3I-201 (50 μM, Selleckchem), P38 inhibitor SB 203580 (10 μM, Selleckchem), or SMAD3 inhibitor SIS3 (3 μM, Selleckchem) for 30 minutes before GSK1016790A treatment.

    Techniques: Expressing, Real-time Polymerase Chain Reaction, BrdU Staining